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Tumor Biology

LLUCC-Biospecimen Laboratory
Loma Linda University Cancer Center Biospecimen Laboratory Specimen Collection Protocol

Mark E. Reeves, MD, PhD


Breast

NSABP-B51
A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

https://clinicaltrials.gov/ct2/show/NCT01872975
Sharon Lum, MD

SWOG-S1418-BR006
A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 as Adjuvant Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Cancer

https://clinicaltrials.gov/ct2/show/NCT02954874
Gayathri Nagaraj, MD

SWOG-A011202
A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy

https://clinicaltrials.gov/ct2/show/NCT01901094
Sharon Lum, MD


GI

Radiation Medicine
Phase I/II Trial of Stereotactic Body Proton Therapy (SBPT) for Patients with Liver Metastases

https://clinicaltrials.gov/ct2/show/NCT01697371
Gary Yang, MD


Pancreas

Investigator Initiated
A Phase II Trial of Pre-operative Chemotherapy (with Gemcitabine and Nab-paclitaxel) and Stereotactic Body Radiotherapy Followed by Surgery and Chemotherapy in Patients with Resectable Pancreatic https://clinicaltrials.gov/ct2/show/NCT03492671
Naveenraj Solomon, MD


Melanoma

SWOG-S1801
A Phase II Randomized Study of Adjuvant vs. Neoadjuvant MK-3475 (Pembrolizumab) for Clinically Detectable Stage III-IV High-Risk Melanoma (NCT #03698019)

https://clinicaltrials.gov/ct2/show/NCT03698019
Mark E. Reeves, MD, PhD


Sarcoma

Radiation Medicine
A phase II study of preoperative proton therapy in soft tissue sarcomas of the extremities and body wall

https://clinicaltrials.gov/ct2/show/NCT01819831
Gary Yang, MD


Acute Care Surgery

1. AAST Vascular Trauma Registry (PROOVIT): The PROspective Observational Vascular Injury Trial
PI: Richard Catalano
Primary PI: Joseph DuBose; University of Maryland, Shock Trauma Center

2. Blunt Thoracic Aortic Injury (BTAI) Prospective Registry
PI: David Turay
Primary PI: Joseph DuBose; University of Maryland, Shock Trauma Center

3. Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA)
PI: David Turay
Primary PI: Joseph DuBose; University of Maryland, Shock Trauma Center

4. Robotic registry for acute care surgery (RR-ACS)
PI: Kaushik Mukherjee

5. Use of Surgical Fixation for Chest Wall Stabilization in Severe Traumatic Rib Fractures
PI: Kaushik Mukherjee
Primary PI: Amanda Celii, MD; University of Oklahoma

6. Brain vs. Bone: Does fracture fixation technique influence outcomes in patients with traumatic brain injury (TBI)?
PI: Sigrid Burruss
Primary PI: Mira Ghneim, MD; R Adams Cowley Shock Trauma Center

7. Subtotal Cholecystectomy for complicated acute cholecystitis: A multicenter prospective observational study
PI: Sigrid Burruss
Primary PI: Kazuhide Matsushima, MD; LAC + USC

8. Anticoagulation in emergency general surgery: Who bleeds more? The ACES trial
PI: Richard Catalano
Primary PI: Lindsay O'Meara, CRNP University of Maryland Medical Center

9. Prospective Multicenter Derivation and Validation of a NECROtizing Soft tissue Infection Score (NECROSIS)
PI: Kaushik Mukherjee
Primary PI: Dennis Kim MD, Harbor-UCLA Medical Center

10. Resuscitative Endovascular Balloon Occlusion (REBOA) and the Use in Placenta Accreta to Minimize Blood Loss
PI: Sigrid Burruss

11. Short versus long duration of antimicrobial therapy after source control for necrotizing skin and soft tissue infections (NECSkin Study)
PI: Kaushik Mukherjee
Primary PI: Michaelia Cucci, PharmD; Cleveland Clinic Akron General

12. Evaluation of Angioembolization for liver injuries with CT identified blush: A Western Trauma Association Multicenter Study.
PI: Sigrid Burruss
Primary PI: Laura Harmon, MD; University of Colorado

13. Multi-Institutional Validation of Trauma Specific Frailty Index
PI: Sigrid Burruss
Primary PI: Bellal Joseph, MD; University of Arizona

14. Prospective comparison of a short versus long chest tube water seal trial for traumatic pneumothorax (CT Pro)
PI: Ryan Hayton
Primary PI: Christopher P. Michetti, MD; Inova Fairfax Hospital

15. Determining Rates of Superficial Surgical Site Infections by Closing Damaged Control Laparotomy Incisions with Wicks
PI: Meghan Cochran-Yu
Primary PI: Katherine Pellizzeri, MD; Prisma Health System

16. Recidivists 2: A study to quantify and describe gunshot wound victims’ recidivism
PI: Sigrid Burruss
Primary PI: Stephanie Bonne, MD; Rutgers New Jersey Medical School

17. Acute Stress Disorder (ASD) Development and Progression after Trauma
PI: Sigrid Burruss

18. Management of Acute Appendicitis and Cholecystitis During the COVID-19 Pandemic: An EAST Multicenter Contemporaneous Cohort Study
PI: Sigrid Burruss
Primary PI: Rondi B. Gelbard, MD FACSUniversity of Alabama at Birmingham

19. Surgical Critical Care during COVID-19 Pandemic
PI: Sigrid Burruss
Primary PI: Shailvi Gupta, MD; University of Maryland

20. Damage-Control Thoracotomy in Thoracic Trauma: Does it Decrease Mortality in Comparison to Definitive Wound Closure Procedures?
PI: Meghan Cochran-Yu
Primary PI: Ashely Meagher, MD; Indiana University School of Medicine

21. Testing the effectiveness of a city and community based violence intervention program
PI: Sigrid Burruss

22. Radiographic Evaluation of Delayed Solid Organ Complications (REDSOC) Study
PI: Martin Rosenthal
Primary PI: Lindsey Perea, MD; Penn Medicine Lancaster General Hospital

23. Outcomes of Early Initiation of Venous Thromboembolism Prophylaxis in Isolated Traumatic Brain Injuries
PI: Martin Rosenthal
Primary PI: Asanthi Ratnasekera, MD; Crozer Regional Trauma Center

24. Cognitive Outcomes and NeuroStimulants among the Cerebrally Injured & Obtunded in the United States: The CONSCIOUS Study
PI: David Turay
Primary PI: Brett Tracy, MD; the Ohio State University Wexner Medical Center

25. Scanning the Aged to Minimize Missed Injury Prospective Observational Study EAST Study Proposal
PI: Esther Yung
Primary PI: Vanessa Ho, MD; MetroHealth Medical Center

26. Contemporary Management of Right Upper Quadrant Gunshot Wounds
PI: Bita Tabrizi
Primary PI: Michael Vella, MD; University of Rochester

27. Social Determinants of Acute Abdomen Outcomes
PI: Sigrid Burruss
Primary PI: The Ohio State University Wexner Medical Center

28. Wound Management in Emergency Colorectal Surgery: To Close or Not to Close?
PI: Daniel Srikurija
Primary PI: Cristina Feather, MD; Anne Arundel Medical Center

29. Low-Titer Type O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patient
PI: Kaushik Mukherjee